You’ll need a laser that can cut through 1/8″ – 1/4″ acrylic. Trotec recommends at least a 60 W CO2 laser (https://www.troteclaser.com/en-ca/knowledge/tips-for-laser-users/material-handling-acrylic/). You’ll also need a commercial fume extractor that can remove the VOCs. BOFA provided our local makerspace a quote on an AD1000IQ for an 80W CO2 laser( https://bofainternational.com/us/find-products/extraction-systems/results/ad-1000-iq/) I’d recommend chatting with a local rep (Epilog, Trotec, BossLaser, etc).
If you haven’t already, you may also want to consider a 3d printer as well for 3d printed keyguards if that’s your main focus. @KenHackbarth has developed a nice set of tools to create these (https://makersmakingchange.com/project/3d-printed-keyguards/).